Mouse models of endocrine tumors
Manuel D Gahete1, Juan M Jimenez-Vacas2, Emilia Alors-Perez3
1M Gahete, Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, 14011, Spain.
The Journal of Endocrinology
|November 27, 2018
Summary
Mouse models are crucial for studying diverse endocrine and neuroendocrine tumors. These models accelerate the discovery of new therapies for these rare and complex cancers.
Area of Science:
- Oncology
- Translational Research
- Animal Models
Background:
- Endocrine and neuroendocrine tumors are diverse and challenging to study due to their heterogeneity and low incidence.
- Understanding their molecular and genetic alterations is key to developing new therapies.
Purpose of the Study:
- To review prominent mouse models for endocrine and neuroendocrine tumors.
- To discuss their generation, characterization, and translatability.
- To highlight clinical implications derived from these models.
Main Methods:
- Review of existing literature on mouse models for endocrine and neuroendocrine tumors.
- Analysis of different in vivo models: cell line-derived xenografts (CDXs), patient-derived xenografts (PDXs), and genetically engineered mouse models (GEMs).
Main Results:
- Various mouse models have been developed and utilized in preclinical, co-clinical, and post-clinical studies.
- These models aid in understanding tumor development, progression, and behavior.
- Results from these models have led to clinical applications and discoveries.
Conclusions:
- Mouse models are indispensable tools for endocrine and neuroendocrine tumor research.
- They facilitate the translation of basic research findings into clinical practice.
- Continued development and application of these models are vital for advancing treatment options.
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