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The BioGRID interaction database: 2019 update.

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Summary
This summary is machine-generated.

The Biological General Repository for Interaction Datasets (BioGRID) archives extensive protein, genetic, and chemical interaction data for humans and model organisms. It now includes CRISPR screen data, enhancing its utility for biological research.

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Area of Science:

  • Biochemistry
  • Genetics
  • Bioinformatics

Background:

  • The Biological General Repository for Interaction Datasets (BioGRID) is a vital open-access resource for biological interaction data.
  • It manually curates and stores protein, genetic, and chemical interactions across major model organisms and humans.

Purpose of the Study:

  • To update and expand the BioGRID database with new interaction data and functionalities.
  • To incorporate chemical interactions and genome-wide CRISPR/Cas9 screen data.
  • To ensure data accessibility and usability for the research community.

Main Methods:

  • Manual curation of biological interactions from scientific literature.
  • Integration of chemical-protein interactions from DrugBank and literature.
  • Annotation of genome-wide CRISPR/Cas9 screens, including gene-phenotype and gene-gene relationships.
  • Development of the Open Repository for CRISPR Screens (ORCS) database.

Main Results:

  • As of September 2018, BioGRID contains over 1.5 million biological interactions from 55,000 publications across 71 species.
  • The database includes over 700,000 post-translational modification sites.
  • The ORCS database houses over 500 genome-wide CRISPR screens.
  • Data is freely available in standard formats and accessible via web services.

Conclusions:

  • BioGRID continues to be a comprehensive and expanding resource for biological interaction data.
  • The inclusion of chemical interactions and CRISPR screen data broadens its scope and research applications.
  • Free and open access to data facilitates integration into various research workflows and platforms.