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Updated: Feb 2, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Mechanisms of Neural Crest Migration

András Szabó1, Roberto Mayor1

  • 1Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom;

Annual Review of Genetics
|November 27, 2018
PubMed

Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs. After induction, the neural crest delaminates and undergoes an epithelial-to-mesenchymal transition before migrating through intricate yet characteristic paths. The neural crest exhibits a variety of migratory behaviors ranging from sheet-like mass migration in the cephalic regions to chain migration in the trunk. During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells' migration.

Keywords:
chemotaxiscollective cell migrationconfinementcontact inhibition of locomotionmorphogenesisneural crest

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