The cytogenetics of childhood leukemia: clinical and biologic implications

Cytogenetic studies have revealed a broad spectrum of abnormalities in the chromosomal make-up of human leukemic cells. These abnormalities are acquired during the process of malignant transformation within the neoplastic clone and reflect the genetic lesions and ablations that have occurred. Because cytogenetic abnormalities are tightly linked to the molecular events that lead to leukemogenesis, it is not surprising that these features correlate with immunophenotypic and morphologic features of the leukemic cells, as well as with the clinical characteristics of children at diagnosis and their responsiveness to therapy. Molecular analysis of the disordered structure or disrupted regulation of genes located at critical chromosomal breakpoints in leukemic cells should continue to provide important insight into normal and aberrant hematopoietic cell function.