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High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
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Bromocriptine-responsive supersellar germinoma with the expression of dopamine receptors: A case report

Yu Peng Wu1, Yi Bao Wang2, Zhe Bao Wu3

  • 12nd Department of Neurosurgery, Liaoning Provincial People's Hospital, Shenyang, 110016, China.

Clinical Neurology and Neurosurgery
|November 27, 2018
PubMed
Abstract

Insights

Dopamine agonists like bromocriptine show potential in treating sellar germinomas, particularly those expressing dopamine receptors. This offers a novel therapeutic avenue for these rare brain tumors.

Area of Science:

  • Neuro-oncology
  • Endocrinology

Background:

  • Germinomas are typically treated with radiotherapy and chemotherapy.
  • The therapeutic potential of dopamine agonists (DAs) on germinomas remains unexplored.

Observation:

  • A patient with a sellar tumor and hyperprolactinemia was treated with bromocriptine.
  • Bromocriptine initially caused an 82% tumor volume reduction.
  • Tumor regrowth occurred, necessitating surgery; histopathology confirmed pure sellar germinoma expressing dopamine 2 and 5 receptors.

Findings:

  • Germinoma cells expressed dopamine 2 and 5 receptors.
  • Bromocriptine demonstrated transient, significant tumor shrinkage.

Implications:

  • Dopamine agonists may represent a novel therapeutic option for germinomas expressing dopamine 2/5 receptors.
  • This suggests a potential targeted therapy approach for specific germinoma subtypes.
Keywords:
BromocriptineDopamine receptorGerminoma

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