Related Experiment Video

Updated: Feb 2, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K

Bleeding and thrombotic events occur early in children on durable ventricular assist devices

Joanna Y Huang1, Vera Ignjatovic2, Bennett J Sheridan3

  • 1Monash University, School of Clinical Sciences, Clayton, Victoria, Australia; Murdoch Children's Research Institute, Hematology Research Group, Parkville, Victoria, Australia; Royal Children's Hospital, Department of Clinical Hematology, Parkville, Victoria, Australia.

Thrombosis Research
|November 27, 2018
PubMed

Insights

Bleeding and thromboembolism (TE) are major risks for children with durable ventricular assist devices (VADs). Most events occurred during heparin use or transition to warfarin, suggesting a need for anticoagulation strategy adjustments.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Biomedical Engineering

Background:

  • Durable ventricular assist devices (VADs) are crucial for managing pediatric end-stage heart failure.
  • Bleeding and thromboembolism (TE) are significant complications in pediatric VAD recipients.

Purpose of the Study:

  • To investigate the timing, incidence, and risk factors for bleeding and TE in children with VADs.

Main Methods:

  • Retrospective cohort study of 44 children implanted with HeartWare HVAD or Berlin Heart EXCOR VADs over 8 years.
  • Analysis of bleeding and TE events, including their timing and association with anticoagulation and antiplatelet therapies.

Main Results:

  • Major bleeding occurred in 39% and TE in 16% (stroke) or 9% (arterial).
  • Most bleeding (66%) and TE (40.5%) events happened during unfractionated heparin therapy.
  • A significant proportion of bleeding (22%) and TE (38%) events occurred during the transition from heparin to warfarin.

Conclusions:

  • Bleeding and TE complications in pediatric VAD patients are frequently linked to unfractionated heparin use or the heparin-to-warfarin transition period.
  • Future research should focus on optimizing anticoagulation and monitoring strategies in the early post-operative phase for pediatric VAD recipients.
Abstract

Keywords:
BleedingHeart failureMechanical circulatory supportPediatricsThrombosisVentricular assist device

More Related Videos

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.1K

Related Concept Videos

Bleeding in Fresh Concrete01:22

Bleeding in Fresh Concrete

Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
578
Brick Durability, Strength, and Appearance01:15

Brick Durability, Strength, and Appearance

Brick durability, strength, and appearance are crucial factors in construction, influencing the choice of bricks for specific applications. The process of freeze-thaw, for instance, significantly affects brick durability. This phenomenon occurs when water absorbed by a brick expands as it freezes, potentially causing damage when it melts and refreezes. Bricks are graded for durability: SW-grade bricks are the most durable, offering high strength and low water absorption, followed by MW-grade...
664
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

4.0K
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
1.4K
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.9K