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Updated: Feb 2, 2026
08:04
Preparation of Functional Silica Using a Bioinspired Method
Published on: August 1, 2018
17.8K
Fluorine-containing block/branched polyamphiphiles forming bioinspired complexes with biopolymers
Olena Paiuk1, Nataliya Mitina1, Miroslav Slouf2
1Lviv Polytechnic National University, S. Bandery str., 12, 79013, Lviv, Ukraine.
Colloids and Surfaces. B, Biointerfaces
|November 27, 2018
Summary
Novel polyamphiphiles containing poly(fluorine-alkyl methacrylate) were synthesized and studied. These polymers form complexes with DNA for gene delivery and with lysozyme for antibacterial applications.
Area of Science:
- Polymer Chemistry
- Biotechnology
- Materials Science
Background:
- Polyamphiphiles with poly(fluorine-alkyl methacrylate) (poly(FMA)) blocks exhibit unique colloidal-chemical properties.
- Understanding these properties is crucial for developing advanced functional materials.
Purpose of the Study:
- To investigate the colloidal-chemical characteristics of novel block/branched cationic and non-ionic polyamphiphiles.
- To explore their potential applications in gene delivery and as antibacterial agents.
Main Methods:
- Synthesis and characterization of polyamphiphiles.
- Surface activity and micelle size measurements.
- Formation and analysis of interpolyelectrolyte complexes with DNA and lysozyme.
- Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), and MALDI-ToF mass spectrometry.
Main Results:
- Established relationships between polymer structure (block lengths, side chain branching) and surface activity/micelle size.
- Developed non-viral polyplexes using poly(FMA)-block-poly(DMAEMA) for plasmid DNA (pDNA) gene delivery.
- Demonstrated disaggregation of lysozyme (LYZ) aggregates by poly(FMA)-block-poly(NVP) and formation of a polyamphiphile–LYS complex with antibacterial activity.
Conclusions:
- The studied polyamphiphiles show tunable properties based on their structural design.
- These polymers are promising candidates for non-viral gene delivery systems.
- Novel polyamphiphile–lysozyme complexes exhibit potential as antibacterial agents.
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