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Clinical Study of Cardiac Autonomic Dysfunction and QT Dispersion in Newly Diagnosed HIV/AIDS Patients and its

Utsav Kumar Sahu1, Maniram Kumhar2

  • 1Resident.

The Journal of the Association of Physicians of India
|November 28, 2018
PubMed

Insights

Cardiac autonomic dysfunction and QT dispersion are common in HIV/AIDS patients, affecting both those with and without AIDS. However, these conditions did not correlate with CD4 count in this study.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Neurology

Background:

  • HIV/AIDS can lead to various complications, including cardiac issues.
  • Cardiac autonomic dysfunction and QT dispersion are potential indicators of cardiovascular health in HIV/AIDS patients.

Purpose of the Study:

  • To assess cardiac autonomic dysfunction and QT dispersion in newly diagnosed HIV/AIDS patients.
  • To investigate the correlation between cardiac autonomic dysfunction and CD4+ T-cell count in HIV/AIDS patients.

Main Methods:

  • Prospective study involving 50 HIV-positive patients (25 with AIDS, 25 without AIDS) and 50 healthy controls.
  • Autonomic function assessed using Ewing's battery of tests.
  • QT dispersion calculated from electrocardiograms.

Main Results:

  • Abnormal autonomic dysfunction observed in 16% of AIDS patients and 4% of HIV-positive patients without AIDS.
  • Abnormal QT dispersion found in 48% of AIDS patients and 16% of HIV-positive patients without AIDS.
  • No statistically significant correlation between cardiac autonomic dysfunction/QT dispersion and CD4+ T-cell count.

Conclusions:

  • Cardiac autonomic dysfunction is prevalent in HIV/AIDS patients, irrespective of AIDS status.
  • QT dispersion is a sensitive marker for cardiac dysautonomia in this population.
  • CD4+ T-cell count does not appear to be a significant predictor of cardiac autonomic dysfunction or QT dispersion in HIV/AIDS.
Abstract

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