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Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic

Leticia Elizondo-Montemayor1,2,3, Gerardo Mendoza-Lara4,5, Gustavo Gutierrez-DelBosque6,7

  • 1Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey N.L. 64710, Mexico. lelizond@itesm.mx.

International Journal of Molecular Sciences
|November 28, 2018
PubMed

Insights

Irisin, a myokine activated by exercise, shows inconsistent effects in children and adolescents. Research links it to body composition and metabolic health, but findings vary significantly with interventions and individual factors.

Area of Science:

  • Pediatric Endocrinology
  • Exercise Physiology
  • Metabolic Health

Background:

  • Irisin, an exercise-induced myokine, has known roles in adult metabolic regulation.
  • Limited and conflicting data exist regarding irisin's impact on pediatric health.
  • Understanding irisin in children is crucial for addressing obesity and metabolic syndrome.

Purpose of the Study:

  • To review existing evidence on irisin in children and adolescents.
  • To analyze irisin's association with body composition, exercise, and metabolic risk factors.
  • To explore factors influencing irisin levels and effects in the pediatric population.

Main Methods:

  • Systematic review of studies on irisin in pediatric populations.
  • Analysis of correlations between irisin and anthropometric parameters.
  • Examination of irisin's relationship with cardiovascular and metabolic markers.
  • Inclusion of data on exercise training and dietetic interventions.

Main Results:

  • Inconsistent correlations found between irisin levels and body composition metrics (BMI, fat mass).
  • Conflicting associations reported for irisin with glucose, insulin resistance, and lipid profiles.
  • Variability in findings based on gender, puberty, exercise type/duration, and diet.

Conclusions:

  • The role of irisin in pediatric health and disease remains unclear due to contradictory evidence.
  • Further research is needed to elucidate irisin's function in children, considering various influencing factors.
  • Potential links between maternal-infant factors and circulating irisin warrant investigation.

Keywords:
body compositioncardiovascular diseasechildrendietirisinmetabolic syndromenutritionobesity, neonatespediatric

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