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Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
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Association between Diabetic Retinopathy and Chronic Periodontitis-A Cross-Sectional Study.

Veena H R1, Sribhargava Natesh2,3, Sudhir R Patil4

  • 1Department of Periodontology, K.L.E Society's Institute of Dental Sciences, Bangalore 560 022, Karnataka, India. drveenahr@gmail.com.

Medical Sciences (Basel, Switzerland)
|November 28, 2018
PubMed
Summary

Diabetic patients with severe periodontal disease (PD) also show more severe diabetic retinopathy (DR). Poorly controlled diabetes, indicated by HbA1c and creatinine levels, is linked to both conditions.

Keywords:
diabetes mellitusdiabetic retinopathyperiodontal disease

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Area of Science:

  • Oral Medicine
  • Ophthalmology
  • Endocrinology

Background:

  • Periodontal disease (PD) is a chronic inflammatory condition affecting the gums and supporting tooth structures.
  • Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus (DM).
  • Similarities in pathogenesis suggest a potential link between PD and DR.

Purpose of the Study:

  • To investigate the association between diabetic retinopathy (DR) and periodontal disease (PD).
  • To correlate the severity of DR with the severity of PD.
  • To examine the relationship between HbA1c, serum creatinine, and periodontal parameters.

Main Methods:

  • Assessed periodontal status in 200 adult diabetic patients (30-65 years) with varying DR severity.
  • Recorded clinical parameters to evaluate PD severity.
  • Measured HbA1c and serum creatinine levels before DR treatment.

Main Results:

  • Found a significant association between diabetes duration, DR severity, and PD severity.
  • Demonstrated a direct correlation between the severity of PD and DR.
  • Observed significant associations between HbA1c/serum creatinine levels and the severity of both DR and PD.

Conclusions:

  • A plausible relationship exists between diabetic retinopathy and periodontal disease.
  • Further prospective studies are needed to confirm if PD influences DR progression.