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Related Concept Videos

Decreasing Function01:27

Decreasing Function

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A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
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Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
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Cell Adhesion in Plants01:14

Cell Adhesion in Plants

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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Formation of Species01:31

Formation of Species

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Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.
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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
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Decrease in VEGF-Induced Pericardial Adhesion Formation Using Bevacizumab After Surgery.

Hosseinali Jelveh Moghaddam1, Marjan Aghajani2, Ehsan Raeis-Abdollahi2

  • 11 Department of anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Surgical Innovation
|November 28, 2018
PubMed
Summary
This summary is machine-generated.

Bevacizumab effectively reduces cardiac adhesions after initial surgery by inhibiting vascular endothelial growth factor (VEGF)-induced angiogenesis, as shown by decreased CD-31 expression. This treatment offers a promising approach to mitigate risks in future cardiac operations.

Keywords:
CD-31adhesion formationbevacizumabinflammatory response

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Area of Science:

  • Cardiovascular Surgery
  • Regenerative Medicine
  • Immunology

Background:

  • Postoperative cardiac adhesions complicate repeat surgeries, increasing risks.
  • Vascular Endothelial Growth Factor (VEGF) is implicated in adhesion formation via inflammatory pathways.

Purpose of the Study:

  • To establish a rat model of postoperative pericardial adhesions.
  • To evaluate the efficacy of bevacizumab, an anti-VEGF antibody, in reducing these adhesions.

Main Methods:

  • Wistar rats underwent sternotomy; bevacizumab or saline was applied locally.
  • Adhesion severity and CD-31 expression (angiogenesis marker) were assessed after 42 days.

Main Results:

  • Bevacizumab significantly reduced mean adhesion scores (0.89 vs 2.56) and CD-31 expression (27.45% vs 56.26%).
  • No significant difference in C-reactive protein levels was observed between groups.

Conclusions:

  • Bevacizumab effectively reduces pericardial adhesion formation post-sternotomy.
  • The mechanism involves preventing VEGF-induced angiogenesis, indicated by CD-31 downregulation.