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Inflammation is correlated with severity and outcome of cerebral venous thrombosis

Liyan Wang1, Jiangang Duan2, Tingting Bian1

  • 1Neurosurgery Department of Xuanwu Hospital Capital Medical University, Changchun st 45, Xicheng District, Beijing, China.

Journal of Neuroinflammation
|November 28, 2018
PubMed

Insights

Inflammation markers are elevated in cerebral venous thrombosis (CVT) and correlate with disease severity and poor outcomes. Neutrophil-to-lymphocyte ratio (NLR) predicts worse prognosis in CVT patients.

Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) is a rare condition with limited understanding of its inflammatory underpinnings.
  • Previous studies suggest a potential link between inflammation and CVT, but detailed analysis across disease stages is lacking.

Purpose of the Study:

  • To investigate inflammatory changes in peripheral blood and cerebrospinal fluid (CSF) at different stages of CVT.
  • To explore the correlation between inflammatory markers, CVT severity, and short-term outcomes.

Main Methods:

  • Retrospective analysis of 95 CVT patients and 41 controls.
  • Measurement of hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6), neutrophil-to-lymphocyte ratio (NLR), and immunoglobulins (IgA, IgM, IgG) in blood and CSF.
  • Assessment of CVT severity using modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and other clinical parameters.

Main Results:

  • Elevated inflammatory markers (Hs-CRP, IL-6, NLR, IgA, IgM, IgG) were observed in CVT patients compared to controls.
  • Inflammatory markers were highest in acute/subacute stages and decreased in the chronic stage.
  • Serum NLR and CSF IgM correlated with baseline disability; Hs-CRP correlated with seizures. NLR, CSF IgA, IgM, and IgG associated with NIHSS scores.
  • Baseline NLR predicted poor short-term outcomes, with NLR ≥ 4.205 indicating high risk.

Conclusions:

  • Inflammation appears to be a consequence of CVT, diminishing over time.
  • Inflammatory markers are significantly associated with disease severity upon admission and predict poor short-term outcomes in CVT.
Abstract

Keywords:
Cerebral venous thrombosisInflammationOutcomeSeverityStage

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