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Related Concept Videos

Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Plasticizers01:31

Plasticizers

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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
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Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Plastic Deformations01:14

Plastic Deformations

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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Plastic Deformations01:19

Plastic Deformations

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Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Feb 2, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

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[Soft tissue sarcomas: limb salvage using reconstructive plastic surgery techniques].

M Lehnhardt1, A Sogorski2, C Wallner2

  • 1Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Referenzzentrum für Gliedmaßentumoren, BG-Universitätskliniken Bergmannsheil Bochum, Ruhr-Universität-Bochum, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland. Marcus.Lehnhardt@bergmannsheil.de.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|November 28, 2018
PubMed
Summary
This summary is machine-generated.

Complete surgical removal is the primary treatment for localized soft tissue sarcomas, aiming for tumor-free margins. Advances in reconstructive surgery allow for limb salvage and functional restoration even with extensive tumors.

Keywords:
AmputationChemotherapyFunctional reconstructionLimb perfusionSurgical flaps

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Plastic and Reconstructive Surgery

Background:

  • Soft tissue sarcomas require complete surgical removal for effective treatment.
  • Achieving tumor-free resection margins (R0 resection) is critical for oncological outcomes.
  • Limb salvage and functional reconstruction are key goals in managing extensive tumors.

Purpose of the Study:

  • To emphasize the importance of complete surgical removal in treating soft tissue sarcomas.
  • To highlight the role of reconstructive surgery in limb salvage and functional restoration.
  • To underscore that R0 resection remains the gold standard for localized soft tissue sarcomas.

Main Methods:

  • Surgical resection of soft tissue sarcomas.
  • Application of reconstructive plastic surgery techniques.
  • Utilization of flap techniques and microsurgery for reconstruction.

Main Results:

  • Complete surgical removal achieves tumor-free resection margins (R0 resection).
  • Reconstructive surgery enables limb salvage in extensive tumor cases.
  • Flap techniques and microsurgery facilitate functional reconstruction post-resection.

Conclusions:

  • Complete surgical removal is the definitive treatment for localized soft tissue sarcomas.
  • R0 resection is paramount for successful oncological management.
  • Modern reconstructive surgery significantly improves functional outcomes and limb preservation in sarcoma treatment.