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Autonomic Nervous System: Overview01:26

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The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
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The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
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Related Experiment Video

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Quantitative Autonomic Testing
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Autonomic dysfunction and HPV immunization: an overview.

Svetlana Blitshteyn1, Louise Brinth2, Jeanne E Hendrickson3

  • 1Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Immunologic Research
|November 28, 2018
PubMed
Summary
This summary is machine-generated.

Severe side effects following HPV vaccination, including fatigue and pain, are reported in case series. These symptoms may stem from immune-mediated autonomic dysfunction, warranting further research into potential causation.

Keywords:
AutoimmunityAutonomic dysfunctionChronic fatigue syndromeChronic regional pain syndromeFibromyalgiaHPV vaccineMyalgic encephalomyelitisPostural orthostatic tachycardia syndromeSmall fiber neuropathy

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Area of Science:

  • Immunology
  • Neurology
  • Vaccinology

Background:

  • Case series from multiple countries report similar symptom clusters in patients experiencing suspected severe side effects after HPV vaccination.
  • These symptoms include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment, altered awareness, and abnormal movements.

Purpose of the Study:

  • To review reported case series of severe side effects following HPV vaccination.
  • To propose a potential mechanism involving vaccine-triggered, immune-mediated autonomic dysfunction.
  • To highlight the need for further research into the causation and predisposition to these adverse events.

Main Methods:

  • Review of published case series describing patients with suspected severe side effects post-HPV vaccination.
  • Analysis of reported symptom clusters and their potential diagnostic labels (e.g., CRPS, POTS, SFN, ME/CFS, fibromyalgia).
  • Discussion of the potential role of autoimmunity and immune-mediated autonomic dysfunction.

Main Results:

  • A consistent constellation of symptoms is observed across reported cases following HPV vaccination.
  • These symptoms overlap with diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and fibromyalgia.
  • Autoimmunity and autoantibodies are noted in a subset of patients with these conditions.

Conclusions:

  • The observed symptom clusters suggest a potential 'post-HPV vaccination syndrome' possibly triggered by immune-mediated autonomic dysfunction in genetically susceptible individuals.
  • While temporal association does not imply causation, the evidence from case series necessitates well-designed studies to investigate the link between HPV vaccines and these symptoms.
  • Future research employing adversomics and pharmacogenetics may identify individuals at risk for HPV vaccine adverse events, aligning with personalized medicine approaches.