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Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

Wu Li1, Wanyan Deng2, Jianping Xie3

  • 1Key Laboratory of Regional Characteristic Agricultural Resources, College of Life Sciences, Neijiang Normal University, Neijiang, China.

Journal of Cellular Physiology
|November 28, 2018
PubMed

Insights

PE/PPE antigens in pathogenic mycobacteria are crucial for tuberculosis pathogenesis and virulence. Understanding their regulation offers new strategies for developing anti-tuberculosis (TB) vaccines and therapies.

Area of Science:

  • Microbiology
  • Immunology
  • Molecular Biology

Background:

  • PE/PPE family antigens are primarily found in pathogenic mycobacteria.
  • These antigens play a role in modulating host immune responses and are linked to mycobacterial pathogenesis.
  • PE/PPE antigens are essential for Mycobacterium tuberculosis (Mtb) growth and exhibit antigenic variation.

Purpose of the Study:

  • To investigate the expression and regulatory networks of PE/PPE family antigens in Mtb.
  • To understand the role of PE/PPE antigens in mycobacterial virulence and pathogenesis.
  • To identify potential targets for novel anti-tuberculosis (TB) measures.

Main Methods:

  • Integrative analysis of PE/PPE antigen expression and regulatory networks.
  • Comparative analysis of pe/ppe gene expression between Mtb and Mycobacterium bovis.
  • Examination of regulatory mechanisms involving transcription factors, sigma factors, and two-component systems.

Main Results:

  • PE/PPE antigens are differentially expressed in pathogenic mycobacteria and are essential for Mtb growth.
  • Expression of PE/PPE antigens is regulated by various factors including Lsr2, MprAB, and PhoPR systems.
  • Analysis revealed complex regulatory networks underlying PE/PPE antigen expression and Mtb virulence.

Conclusions:

  • PE/PPE antigens are key players in Mtb pathogenesis and virulence.
  • Understanding the regulation of PE/PPE antigens provides insights into host-pathogen interactions.
  • These findings offer potential avenues for developing new anti-TB vaccines and therapeutic strategies.
Keywords:
Mycobacterium tuberculosisPE/PPEexpression patternmulti-scale analysesregulatory network

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