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Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
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Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

383

Association between miRNAs expression and signaling pathways of oxidative stress in diabetic retinopathy

Mahbobeh Satari1, Esmat Aghadavod1, Moein Mobini2

  • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Depatrment of Biochemistry, Kashan University of Medical Sciences, Kashan, Iran.

Journal of Cellular Physiology
|November 28, 2018
PubMed

Insights

Diabetic retinopathy (DR) is a leading cause of vision loss. This study investigates how microRNAs (miRNAs) and oxidative stress contribute to DR development and progression, exploring their potential as disease markers.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic retinopathy (DR) significantly impairs vision in diabetic individuals.
  • Hyperglycemia and oxidative stress are key contributors to DR pathogenesis.
  • MicroRNAs (miRNAs) are increasingly recognized for their role in DR etiology and progression.

Purpose of the Study:

  • To examine the function and expression levels of specific miRNAs.
  • To investigate the involvement of these miRNAs in oxidative stress pathways.
  • To elucidate the role of miRNAs in the pathogenesis of diabetic retinopathy.

Main Methods:

  • Analysis of miRNA expression levels in relation to oxidative stress markers.
  • Investigation of miRNA targets within oxidative stress-related pathways.
  • Correlation of miRNA changes with DR severity and progression.

Main Results:

  • Identified specific miRNAs implicated in DR pathogenesis.
  • Demonstrated a link between miRNA expression and oxidative stress pathways in DR.
  • Established miRNAs as potential biomarkers for DR severity.

Conclusions:

  • MicroRNAs play a crucial role in the development and progression of diabetic retinopathy.
  • Targeting miRNAs involved in oxidative stress pathways may offer therapeutic strategies for DR.
  • miRNAs show promise as stable and accessible biomarkers for detecting DR severity.
Keywords:
diabetic retinopathymiRNAsoxidative stress

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