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Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes
Reena Sheoran1, Sukhbir Lal Khokra1, Viney Chawla2
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, India.
Recent Patents on Nanotechnology
|November 28, 2018
Summary
Liposomes, versatile phospholipid vesicles, are effective carriers for various agents, including drugs and vaccines. Their biocompatibility and diverse applications in nanomedicine highlight their therapeutic potential.
Area of Science:
- Nanotechnology and Pharmaceutical Sciences
Background:
- Liposomes are spherical vesicles composed of phospholipid bilayers, serving as efficient carriers for diverse bioactive agents.
- They possess the unique ability to encapsulate both lipophilic and hydrophilic compounds, facilitating controlled release applications.
- Liposomes are recognized for their biocompatible, biodegradable, non-toxic, and non-immunogenic properties, making them attractive for therapeutic uses.
Purpose of the Study:
- To provide a comprehensive overview of liposomes, covering their classification and formulation.
- To review the characterization techniques, patented formulations, and broad applications of liposomes.
- To discuss the future prospects and potential of liposomal technology.
Main Methods:
- Liposomes are prepared using various techniques, including sonication, ethanol injection, lipid film hydration, and micro-emulsion methods.
- Cell-specific targeting is a key feature enabling applications in nanotechnology.
- Formulation and characterization are crucial steps in developing effective liposomal products.
Main Results:
- Liposomes demonstrate significant potential in drug delivery, diagnostics, vaccine development, and nutrient transport.
- Their application extends to cancer therapy, gene delivery, cosmetics, agriculture, and food technology.
- Extensive research has focused on optimizing liposomal formulations for enhanced drug and gene delivery.
Conclusions:
- This review consolidates information on liposome classification, formulation, characterization, and applications.
- Liposomes offer a promising platform for advanced therapeutic and diagnostic strategies.
- Future research directions and prospects for liposomal technology are highlighted.
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