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Updated: Aug 15, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
The underfilled coronary artery: some pre- and post-operative observations on recipient arterial quality and left
Insights
Saphenous vein bypass graft occlusion rates were 12% overall. Arteries with specific pre-operative characteristics, like underfilling, showed a lower occlusion rate post-surgery, impacting cardiac function.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Vascular Imaging
Background:
- Saphenous vein grafts are commonly used for coronary artery bypass grafting.
- Early graft patency is crucial for successful surgical outcomes.
- Routine restudy is performed to assess graft status post-operation.
Purpose of the Study:
- To evaluate the early occlusion rate of saphenous vein aortocoronary bypass grafts.
- To identify factors associated with graft occlusion.
- To assess the impact of graft patency on left ventricular ejection fraction.
Main Methods:
- Analysis of 141 saphenous vein grafts in 59 patients via coronary angiography within four weeks of surgery.
- Assessment of graft patency and correlation with pre-operative arterial characteristics.
- Comparison of pre-operative and post-operative left ventricular ejection fraction.
Main Results:
- An overall graft occlusion rate of 12% was observed.
- Trends towards higher occlusion were noted in small arteries, those with limited run-off, significant distal disease, or severe atheroma.
- Arteries identified as underfilled pre-operatively demonstrated a significantly increased diameter post-operatively with a low occlusion rate (7%).
- Patent grafts correlated with a significant increase in left ventricular ejection fraction, while occluded grafts did not.
Conclusions:
- Early graft occlusion in saphenous vein bypass surgery is multifactorial.
- Specific pre-operative angiographic findings, particularly underfilled arteries, may predict successful graft outcomes.
- Graft patency is directly linked to improved post-operative cardiac function.
Abstract:
In a series of 141 saphenous vein aortocoronary bypass grafts in 59 patients undergoing routine restudy of the coronary arteries within four weeks of operation, an overall graft occlusion rate of 12% was found. A trend towards a higher occlusion rate was seen in arteries that were small (19%), that had a limited run-off (15%), significant distal disease (24%) or severe atheroma at the graft site (22%). Statistically, these occlusion rates are not significantly different from the overall failure rate and do not give absolute contra-indications to grafting. A particular group of arteries which seemed underfilled in the pre-operative angiogram (1.5 mm or less in diameter but apparently healthy with smooth walls and supplying a larger area of myocardium than would be expected from their apparent size) was identified. These arteries showed a significant increase in diameter in the post-operative angiograms and had a low occlusion rate (1 of 15 grafts; 7%). When all grafts were patent, the mean post-operative left ventricular ejection fraction showed a significant increase over the pre-operative valve, but when one or more grafts were occluded there was no significant change.
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