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Updated: Feb 2, 2026

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Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models
Published on: March 6, 2018
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ESTIMATION OF A MONOTONE DENSITY IN S-SAMPLE BIASED SAMPLING MODELS.
Kwun Chuen Gary Chan1, Hok Kan Ling2, Tony Sit3
1Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Summary
This study establishes the existence, uniqueness, and consistency of a monotone maximum likelihood estimator for decreasing density functions in biased sampling models. It also determines the estimator's asymptotic distribution, filling a significant gap in statistical literature.
Area of Science:
- Statistics
- Nonparametric Inference
- Biased Sampling Models
Background:
- The estimation of decreasing density functions in biased sampling models is crucial for various statistical applications.
- Existing literature lacks methods for determining the monotone maximum likelihood estimator and its asymptotic distribution for s > 1 samples due to complex likelihood structures.
Purpose of the Study:
- To develop and validate a monotone maximum likelihood estimator (ĝ) for decreasing density functions in general s-sample biased sampling models.
- To establish the existence, uniqueness, consistency, and asymptotic distribution of the proposed estimator.
Main Methods:
- Developed a novel approach to address the non-standard structures of the likelihood function, including non-separability.
- Employed purely analytic arguments to demonstrate the tightness of the estimator, avoiding traditional geometric methods.
- Proposed an indirect strategy to achieve the convergence rate for linear functionals involving weight functions.
Main Results:
- Successfully established the existence, uniqueness, self-characterization, and consistency of the monotone maximum likelihood estimator (ĝ).
- Determined the asymptotic distribution of ĝ at a fixed point, resolving a long-standing problem for s > 1.
- Provided a method to achieve the convergence rate for the linear functional ∫ w.
Conclusions:
- The study successfully addresses the challenges in nonparametric estimation of decreasing densities under biased sampling.
- The established theoretical properties of the monotone maximum likelihood estimator provide a robust tool for statistical analysis.
- This work significantly advances the understanding and application of biased sampling models in statistical inference.
Keywords:
Karush-Kuhn-Tucker conditionsdensity estimationempirical process theorynonparametric estimationorder statistics from multiple sampless-sample biased samplingself-induced characterizationshape-constrained problemMore Related Videos
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