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Updated: Feb 2, 2026
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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
20.2K
Understanding neonatal hypoxic-ischemic encephalopathy with metabolomics
N Efstathiou1, G Theodoridis2, K Sarafidis1
11 Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hippokratia
|November 28, 2018
Summary
Metabolomics offers new insights into metabolic changes in newborns with hypoxic-ischemic encephalopathy (HIE). This approach may lead to better diagnostic and therapeutic tools for HIE, a serious complication of perinatal asphyxia.
Area of Science:
- Biochemistry
- Neonatal Medicine
- Neuroscience
Background:
- Hypoxic-ischemic encephalopathy (HIE) is a severe condition following perinatal asphyxia, often resulting in poor outcomes.
- Understanding the biological alterations in HIE is crucial for developing new diagnostic and therapeutic strategies.
- Metabolomics is an emerging field for studying perinatal asphyxia and HIE.
Purpose of the Study:
- To review and synthesize findings from metabolomic studies in perinatal asphyxia/HIE.
- To explore the potential of metabolomics in explaining metabolic changes and guiding treatment.
- To discuss the clinical relevance of metabolomic findings for bedside clinicians.
Main Methods:
- Conducted a narrative, non-systematic literature review.
- Included metabolomic studies on newborn animals and humans with hypoxia-ischemia or HIE.
- Evaluated fifteen animal studies, nine human neonatal studies, and two review articles.
Main Results:
- Presented changes in metabolomic profiles of animals and neonates affected by hypoxia-ischemia/HIE.
- Related these metabolic alterations to the underlying pathophysiology of HIE.
- Discussed the clinical applicability of the findings for patient care.
Conclusions:
- Metabolomics can elucidate the metabolic disturbances in perinatal asphyxia/HIE.
- This approach may clarify the biological basis of therapeutic interventions.
- Metabolomics holds promise for developing novel diagnostic and prognostic biomarkers for HIE.
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