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2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience.

Ke Yang1, XianHui Ding1, ZhiMing Zhou1

  • 1Department of Neurology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, China.

Translational Neuroscience
|November 28, 2018
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Summary
This summary is machine-generated.

The index to ring finger length (2D:4D) ratio, a marker for prenatal hormone exposure, showed a limited diagnostic value for ischemic stroke. Further research is needed to explore its potential role in screening for this condition.

Keywords:
2D:4D ratiobiomarkerfinger lengthischemic stroke

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Area of Science:

  • Endocrinology
  • Neurology
  • Biomarkers

Background:

  • The 2D:4D digit ratio serves as a biomarker for prenatal sex hormone exposure.
  • Sex hormones are implicated in the development of ischemic stroke.
  • Understanding potential biomarkers for stroke is crucial for early detection and prevention.

Purpose of the Study:

  • To investigate the association between the 2D:4D digit ratio and the occurrence of ischemic stroke.
  • To evaluate the predictive performance of the 2D:4D ratio for identifying individuals at risk of ischemic stroke.

Main Methods:

  • Retrospective analysis of 100 first-ever ischemic stroke patients.
  • Measurement of index and ring finger lengths to calculate 2D:4D ratios.
  • Utilized Receiver Operating Characteristic (ROC) analysis to assess predictive accuracy.

Main Results:

  • Ischemic stroke patients exhibited higher 2D:4D ratios compared to controls, with exceptions in females.
  • ROC analysis indicated a moderate predictive performance for 2D:4D ratios in identifying ischemic stroke, particularly in males.
  • No significant correlation was found between 2D:4D ratio and stroke severity.

Conclusions:

  • The 2D:4D digit ratio has limited diagnostic utility for ischemic stroke.
  • Further investigation is warranted to determine the role of the 2D:4D ratio in ischemic stroke screening.