Related Experiment Video

Updated: Feb 2, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
05:20

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

8.1K

Crescendo Transient Ischemic Attacks Due to Basilar Coccidioidal Meningitis With Coccidioma

Carlos D'Assumpcao1,2, Arash Heidari1,3, Katayoun Sabetian1

  • 1Kern Medical-UCLA, Bakersfield, CA, USA.

Journal of Investigative Medicine High Impact Case Reports
|November 28, 2018
PubMed

Insights

Coccidioidal meningitis can mimic strokes, presenting uniquely as transient ischemic attacks. Early diagnosis and conservative fluconazole treatment showed positive outcomes in this rare case.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Mycology

Background:

  • Coccidioidal meningitis is a serious fungal infection of the central nervous system.
  • Typical symptoms include headache, fever, altered mental status, and focal neurological deficits.
  • It often requires long-term antifungal therapy.

Purpose of the Study:

  • To report a unique case of coccidioidal meningitis presenting as crescendo transient ischemic attacks (TIAs).
  • To highlight the importance of considering coccidioidal meningitis in the differential diagnosis of TIAs.
  • To demonstrate the efficacy of conservative management in a patient with coccidioidal meningitis.

Main Methods:

  • Case report of a patient with coccidioidal meningitis.
  • Clinical presentation analysis, including neurological examination and imaging.
  • Treatment response evaluation with fluconazole and dexamethasone.

Main Results:

  • The patient initially presented with four consecutive crescendo TIAs with transient focal neurological deficits.
  • Imaging revealed a left basilar coccidioma, a fungal granuloma.
  • Four-month follow-up demonstrated a positive treatment response to oral fluconazole (1000 mg) and a dexamethasone taper.

Conclusions:

  • Crescendo cerebrovascular TIAs can be an unusual initial presentation of coccidioidal meningitis.
  • Prompt recognition and appropriate antifungal therapy are crucial for favorable outcomes.
  • Conservative management with fluconazole can be effective for coccidioidal meningitis.
Keywords:
coccidioidal meningitiscoccidioidomycosiscrescendo transient ischemic attack

More Related Videos

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

10.5K
Recording of Inward Rectifying K+ Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique07:19

Recording of Inward Rectifying K+ Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique

Published on: February 7, 2025

740

Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.0K
Acid Attack on Concrete01:21

Acid Attack on Concrete

When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
756
Sulfate Attack on Concrete01:29

Sulfate Attack on Concrete

Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
740
Series R—L Circuit Transients01:22

Series R—L Circuit Transients

In a series resistor-inductor (R-L) circuit, closing the switch at the start of the time period simulates a three-phase short circuit, a fault condition where all three phases of an unloaded synchronous machine are short-circuited. When there is no fault impedance and no initial current, the initial voltage is determined by the phase angle of the source voltage.
Using Kirchhoff's Voltage Law (KVL) to analyze this circuit helps determine the total asymmetrical fault current, which consists...
397
Transient and Steady-state Response01:24

Transient and Steady-state Response

In control systems, test signals are essential for evaluating performance under various conditions. The ramp function is effective for systems undergoing gradual changes, while the step function is suitable for assessing systems facing sudden disturbances. For systems subjected to shock inputs, the impulse function is the most appropriate test signal.
These test signals are integral in designing control systems to exhibit two key performance aspects: transient response and steady-state...
566
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.4K