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[Malignant histiocytosis (author's transl)].

D Huhn, P Meister, E Thiel

    Deutsche Medizinische Wochenschrift (1946)
    |January 13, 1978
    PubMed
    Summary

    Malignant histiocytosis involves rapid growth of abnormal histiocytes in organs like the spleen and liver. Diagnosis utilizes electron microscopy and specific tests, differentiating it from lymphatic cancers.

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    miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP.

    Oncogene·2014

    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Malignant histiocytosis is a rare neoplastic proliferation of atypical histiocytes.
    • Understanding its clinical and pathological features is crucial for accurate diagnosis and management.

    Observation:

    • Observations in six patients and literature review detailed the characteristic multifocal proliferation of atypical histiocytes.
    • Key affected organs include lymph nodes, spleen, liver, bone marrow, and lungs.
    • Clinical manifestations frequently include fever, anemia, leukopenia with T-lymphocyte reduction, and jaundice.

    Findings:

    • Diagnosis is supported by electron microscopy, enzyme, and immunocytochemical tests.
    • Immunoglobulin levels are typically normal or show polyclonal increase.
    • Malignant histiocytosis exhibits characteristics more aligned with monocyte leukemia and histiocytosis X than with lymphoid neoplasms.

    Implications:

    • Accurate differentiation from lymphoid neoplasms is essential for appropriate therapeutic strategies.
    • Further research into the specific cell lineage and pathogenesis of malignant histiocytosis is warranted.
    • Early diagnosis through advanced testing can potentially improve patient outcomes.

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