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Updated: Feb 2, 2026

Experimental Approaches to Tissue Engineering
Published on: August 30, 2007
Big bottlenecks in cardiovascular tissue engineering
Ngan F Huang1,2,3, Vahid Serpooshan4,5,6, Viola B Morris5,7
1Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
None:
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.
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