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Updated: Feb 2, 2026
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
Perfusion-Phase [18F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
Matthias Brendel1, Leonie Wagner1, Johannes Levin2
1Department of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Abstract:
We aimed to test if early, perfusion phase tau-PET imaging with [18F]THK5351 might substitute for [18F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and positive amyloid-PET was examined by [18F]THK5351 tau-PET and [18F]FDG PET. The pattern of early phase of [18F]THK5351 uptake was compared to [18F]FDG visually and by the dice similarity coefficient. Visual inspection of axial slices and stereotactic-surface projection indicated a striking agreement between combined 0-2 min p.i. perfusion images of [18F]THK5351 and standard [18F]FDG 30-60 min p.i. A two-phase protocol of [18F]THK5351 PET might give information on neurodegeneration and tau pathology in a single session.
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