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Studies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence

M Govindaraju1, K S Rao Jayanth2,3, D Jagadeesh Kumar4

  • 1Department of Molecular Biophysics, Indian Institute of Science, Bangalore, India.

Journal of Alzheimer'S Disease Reports
|November 28, 2018
PubMed
Summary

Copper and amyloid-beta peptide alter DNA structure, potentially contributing to neurodegenerative diseases. This study reveals how these factors impact DNA conformation and stability.

Keywords:
Circular dichroismconformationneurodegenerationtrinucleotides

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