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Formal Synthesis of (+)-Phomactin A
Junrong Huang1, Wenli Bao1, Shuangping Huang1
1Key State Laboratory of Chemical Cancer Genomics , Peking University Shenzhen Graduate School, Shenzhen University Town , Xili, Shenzhen 518055 , China.
Abstract:
A concise formal synthesis of (+)-phomactin A has been achieved. The key features of this synthetic strategy involve a one-pot Prins/Conia-ene cyclization protocol for the construction of the highly functionalized 1-oxadeclin core (AB ring) and a late-stage direct γ-hydroxylation of enone for the installation of the C ring.
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