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Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish
Junya L Singulani1, Reginaldo S Pedroso2,3, Arthur B Ribeiro2
1Universidade Estadual Paulista Julio de Mesquita Filho, 14800-903, Araraquara, SP, Brazil.
Future Microbiology
|November 28, 2018
Summary
Geraniol and linalool show antifungal properties against Candida species. However, high concentrations of these compounds also demonstrate genotoxic and embryotoxic effects in laboratory tests.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Toxicology
Background:
- Geraniol and linalool are key components found in the essential oils of various medicinal plants.
- These natural compounds are recognized for their diverse biological activities.
Purpose of the Study:
- To investigate the antifungal efficacy of geraniol and linalool against five species of Candida.
- To assess the genotoxicity and embryotoxicity of geraniol and linalool using established laboratory models.
Main Methods:
- Antifungal activity was tested against five Candida species.
- Genotoxicity was evaluated using the cytokinesis-block micronucleus test.
- Embryotoxicity was assessed using a zebrafish model to determine LC50 values.
Main Results:
- Both geraniol and linalool exhibited inhibitory effects on Candida growth, with geraniol being more potent.
- Significant chromosome damage was observed at 800 μg/ml for geraniol and 125 μg/ml for linalool.
- Geraniol displayed higher toxicity to zebrafish embryos (LC50 = 31.3 μg/ml) compared to linalool (LC50 = 193.3 μg/ml).
Conclusions:
- Geraniol and linalool possess notable anticandidal activity.
- These compounds also exhibit genotoxic and embryotoxic potential at elevated concentrations, warranting careful consideration for therapeutic applications.
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