Related Experiment Video
Updated: Feb 2, 2026

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
Published on: August 25, 2022
Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish
Junya L Singulani1, Reginaldo S Pedroso2,3, Arthur B Ribeiro2
1Universidade Estadual Paulista Julio de Mesquita Filho, 14800-903, Araraquara, SP, Brazil.
Aim:
Geraniol and linalool are major constituents of the essential oils of medicinal plants.
Materials & Methods:
Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model.
Results:
Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800 μg/ml and the linalool at concentration of 125 μg/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3 μg/ml, respectively.
Conclusion:
Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations.
Related Concept Videos
Thermodynamics: Chemical Potential and Activity
The thermodynamic equilibrium constant is more accurately defined in terms of activity rather than concentration.
Potential Energy
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Potential Energy
Standard Electrode Potentials
Cell Potential and Free Energy
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
The Resting Membrane Potential

