Related Experiment Video
Updated: Feb 2, 2026
05:20
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
3.2K
Advances in neuroblastoma therapy.
Suzanne MacFarland1,2, Rochelle Bagatell1,2
1Division of Oncology, The Children's Hospital of Philadelphia.
Current Opinion in Pediatrics
|November 28, 2018
Summary
Advances in understanding neuroblastoma biology and genetics are refining risk stratification. This enables personalized treatment strategies, improving outcomes for neuroblastoma patients.
Area of Science:
- Pediatric Oncology
- Cancer Genetics
- Immunotherapy
Background:
- Neuroblastoma understanding has grown, including its genetic basis and host factors.
- Progress in neuroblastoma predisposition and treatment approaches is evident.
- Current therapies have improved outcomes, though high-risk neuroblastoma survival remains challenging.
Purpose of the Study:
- To review current and future risk-based treatment strategies for neuroblastoma.
- To discuss challenges and opportunities in selecting optimal therapies for patient subsets.
- To highlight advancements in neuroblastoma biology and host factor roles.
Main Methods:
- Review of recent scientific literature on neuroblastoma.
- Analysis of current and emerging treatment modalities.
- Evaluation of risk stratification and biomarker development.
Main Results:
- New prognostic markers are being integrated for precise risk classification.
- Targeted therapies and immunotherapeutics show promise in clinical trials.
- Predictive biomarkers are under development for refined treatment assignment.
Conclusions:
- Evolving neuroblastoma therapy relies on deeper biological understanding.
- Improved risk stratification and biomarkers will enhance treatment selection.
- Future neuroblastoma treatments are expected to be more effective and less toxic.
Related Concept Videos
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
02:22Overview of Advanced Functional Groups
29.9K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.9K
00:56Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
01:26Group Therapy
443
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
443
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
01:22Behavior Therapy
705
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
705