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Updated: Feb 2, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

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Dynamics and Challenges of Clinical Trials in Adolescents and Young Adults With Cancer

Lorna A Fern, Archie Bleyer

    Cancer Journal (Sudbury, Mass.)
    |November 28, 2018
    PubMed

    Insights

    Adolescent and young adult cancer patients are underrepresented in clinical trials, hindering outcome improvements. This review examines barriers and facilitators to enhance adolescent and young adult (AYA) recruitment in cancer research.

    Area of Science:

    • Oncology
    • Clinical Trials
    • Adolescent and Young Adult (AYA) Health

    Background:

    • Clinical trial participation is the standard of care for cancer patients, improving outcomes.
    • Adolescent and young adult (AYA) cancer patients are significantly underrepresented in research.
    • Outcome improvements for AYAs lag behind pediatric and adult populations due to low trial enrollment.

    Purpose of the Study:

    • To review the recruitment of adolescent and young adult (AYA) patients into cancer clinical trials.
    • To identify and discuss barriers contributing to AYA underrepresentation.
    • To explore facilitators that can improve AYA enrollment in cancer research.

    Main Methods:

    • Systematic review of existing literature on AYA cancer clinical trial recruitment.
    • Analysis of identified barriers and facilitators impacting enrollment rates.
    • Discussion of evidence-based strategies to improve AYA participation.

    Main Results:

    • AYA cancer patients face unique barriers to clinical trial participation.
    • Systematically tested interventions to improve AYA recruitment are lacking.
    • Recruitment rates for AYAs remain lower than for pediatric populations.

    Conclusions:

    • Addressing AYA underrepresentation in cancer trials is critical for advancing their care.
    • Developing and implementing targeted interventions can improve AYA enrollment.
    • Facilitating AYA participation in clinical trials is essential for equitable progress in cancer research.

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