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Related Concept Videos

Aging01:26

Aging

705
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

236
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
236
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

703
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
703
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

262
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
262

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Erratum: Welcome to Innovation in Aging.

Laura P Sands1, Steven M Albert2, J Jill Suitor3

  • 1Department of Human Development and Center for Gerontology, Virginia Tech, Blacksburg.

Innovation in Aging
|November 28, 2018
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Summary

This study corrects previously published article DOIs. It ensures accurate citation and retrieval of scientific literature for researchers.

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Area of Science:

  • Bibliometrics
  • Scientific Publishing
  • Scholarly Communication

Context:

  • Accurate tracking of scientific publications is crucial for research integrity.
  • Digital Object Identifiers (DOIs) are essential for uniquely identifying and linking scholarly articles.
  • Errors in DOIs can impede literature searches and citation analysis.

Purpose:

  • To correct erroneous Digital Object Identifiers (DOIs) associated with a specific scientific article.
  • To ensure the accurate linkage and discoverability of published research.
  • To maintain the integrity of the scientific record.

Summary:

  • The article provides corrections for the Digital Object Identifiers (DOIs) previously assigned to a publication.
  • These corrections address specific DOI errors, ensuring proper referencing.
  • The updated DOIs facilitate correct access and citation of the research.

Impact:

  • Enhances the reliability of scientific literature databases.
  • Improves the accuracy of citation tracking and bibliometric analysis.
  • Facilitates seamless access to the corrected article for the scientific community.