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Probiotics for treating eczema.

Areti Makrgeorgou1, Jo Leonardi-Bee, Fiona J Bath-Hextall

  • 1Department of Dermatology, West Ambulatory Care Hospital, Dalnair Street, Glasgow, UK, G3 8SJ.

The Cochrane Database of Systematic Reviews
|November 28, 2018
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Summary
This summary is machine-generated.

Probiotics likely offer no significant benefit for eczema symptoms or quality of life. Current evidence suggests probiotics are not an evidence-based treatment for eczema, with a small risk of adverse events.

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Area of Science:

  • Dermatology
  • Microbiology
  • Gastroenterology

Background:

  • Eczema is a prevalent chronic skin condition.
  • Probiotics are increasingly explored for eczema treatment, with ongoing clinical trials.
  • Previous reviews indicated limited efficacy and areas needing more evidence.

Purpose of the Study:

  • To evaluate the effectiveness of probiotics in treating eczema across all age groups.
  • To update previous systematic reviews on probiotics for eczema.

Main Methods:

  • Updated systematic search of multiple databases (e.g., Cochrane Library, MEDLINE, Embase) up to January 2018.
  • Inclusion of 39 randomized controlled trials (RCTs) involving 2599 participants with doctor-diagnosed eczema.
  • Assessment of participant-rated symptoms, quality of life (QoL), investigator-rated severity (SCORAD), and adverse events.

Main Results:

  • Probiotics showed little to no difference in participant- or parent-rated eczema symptoms (moderate-quality evidence).
  • No significant difference in QoL was observed (low-quality evidence).
  • A small, potentially not clinically significant, reduction in investigator-rated eczema severity was noted (low-quality evidence).

Conclusions:

  • Current probiotic strains offer minimal to no improvement in eczema symptoms or QoL.
  • The observed effect on investigator-rated severity was small and of uncertain clinical significance.
  • Probiotic use for eczema is not currently evidence-based, with a small risk of gastrointestinal adverse events.