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Related Concept Videos

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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Related Experiment Video

Updated: Feb 2, 2026

Reverse Total Shoulder Arthroplasty
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Progressive discoloration over the right shoulder.

Matthew F Helm1, David Cole1, Elizabeth V Seiverling2

  • 1Departments of Dermatology and Family Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

The Journal of Family Practice
|November 28, 2018
PubMed
Summary

A previously noted skin discoloration on the shoulder showed new growth and hypertrichosis (excessive hair growth). This prompted further dermatological investigation into the evolving skin lesion.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Skin lesions can present with varied clinical manifestations.
  • Changes in size and texture warrant diagnostic evaluation.

Observation:

  • A pre-existing discolored skin patch on the shoulder exhibited significant enlargement.
  • The lesion also developed hypertrichosis, characterized by abnormal hair growth.

Findings:

  • The evolving nature of the skin lesion, including increased size and hypertrichosis, indicated a need for detailed examination.
  • Further investigation aimed to determine the underlying cause of these changes.

Implications:

  • Understanding the progression of skin lesions is crucial for accurate diagnosis.
  • Early detection of changes in dermatological conditions can improve patient outcomes.