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Phosphinic acids: current status and potential for drug discovery
Moaz M Abdou1, Paul M O'Neill2, Eric Amigues3
1Egyptian Petroleum Research Institute, Nasr City, PO 11727, Cairo, Egypt; Department of Chemistry, Xi'an Jiaotong Liverpool University, Suzhou, Jiangsu 215123, PR China; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
Drug Discovery Today
|November 28, 2018
Summary
Phosphinic acid derivatives show broad biological activities, making them valuable in medicinal chemistry for developing new drugs. This review covers their progress against various diseases, including prodrugs and clinical applications.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Organic Synthesis
Background:
- Phosphinic acid derivatives possess diverse biological activities and structural variety.
- These compounds are increasingly recognized for their significant impact in medicinal chemistry.
- Previous and recent research underscores their therapeutic potential.
Purpose of the Study:
- To review key breakthroughs in the development of phosphinic acid derivatives as medicinal agents.
- To highlight their pharmacological activities against a wide spectrum of diseases.
- To summarize the clinical status of phosphinic acid-based prodrugs and drug-delivery systems.
Main Methods:
- Literature review of recent and previous research on phosphinic acid derivatives.
- Analysis of pharmacological activities reported for these compounds.
- Assessment of the current clinical development status of related prodrugs and delivery systems.
Main Results:
- Phosphinates demonstrate efficacy against numerous diseases, including inflammation, Alzheimer's, parasitic infections, hepatitis, and cancers.
- Significant activity was observed against viral infections (HIV, influenza) and malaria.
- Antimicrobial properties of phosphinic acid derivatives were also highlighted.
Conclusions:
- Phosphinic acid derivatives represent a versatile and promising scaffold for novel therapeutic agents.
- Their broad spectrum of activity and ongoing clinical development indicate substantial future potential in medicine.
- Further research into phosphinic acid-based prodrugs and delivery systems is warranted.
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