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Updated: Feb 2, 2026

Studying Protein Import into Chloroplasts Using Protoplasts
Published on: December 10, 2018
Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development
Vishal C Kalel1, Pascal Mäser2, Michael Sattler3
1Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, 44780 Bochum, Germany.
Abstract:
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
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