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Autologous serum eye drops show potential for dry eye treatment, but standardization is needed. New research highlights selenoprotein P (SeP) as a promising therapeutic candidate for dry eye disease.

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Regenerative Medicine

Background:

  • Dry eye syndrome is a complex ocular surface condition.
  • Autologous serum eye drops have been used since 1975, but their efficacy is debated due to lack of standardization.
  • Serum components share similarities with natural tear components, suggesting therapeutic potential.

Purpose of the Study:

  • To evaluate the efficacy of autologous serum eye drops for dry eye treatment.
  • To investigate selenoprotein P (SeP) as a novel therapeutic agent for dry eye.
  • To develop and utilize an oxidative stress-induced dry eye model for screening antioxidative molecules.

Main Methods:

  • Systematic review of autologous serum eye drop efficacy.
  • Administration of SeP eye drops to a dry eye rat model.
  • Assessment of corneal fluorescein scores and oxidative stress markers.
  • Development of a novel oxidative stress-induced dry eye model.

Main Results:

  • Efficacy of autologous serum eye drops remains ambiguous due to non-standardized preparation and application.
  • SeP eye drops significantly reduced corneal fluorescein scores in a dry eye rat model.
  • SeP treatment suppressed corneal oxidative stress, ameliorating corneal disorder.

Conclusions:

  • Standardized, high-quality clinical trials are necessary to confirm autologous serum eye drop efficacy.
  • Selenoprotein P demonstrates significant therapeutic potential for treating dry eye disease.
  • The newly developed oxidative stress model is valuable for identifying antioxidative treatments for dry eye.