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Updated: Feb 2, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Functional optical coherence tomography of retinal photoreceptors
Xincheng Yao1,2, Taeyoon Son1, Tae-Hoon Kim1
11 Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Impact Statement:
Retinal photoreceptors are the primary target of age-related macular degeneration (AMD) which is the leading cause of severe vision loss and legal blindness. An objective method for functional assessment of photoreceptor physiology can benefit early detection and better treatment evaluation of AMD and other eye diseases that are known to cause photoreceptor dysfunctions. This article summarizes in vitro study of IOS mechanisms and in vivo demonstration of IOS imaging of intact animals. Further development of the functional IOS imaging may provide a revolutionary solution to achieve objective assessment of human photoreceptors.
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