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Tremor.

Hugo Morales-Briceño¹, Alessandro F Fois¹, Victor S C Fung²

¹Movement Disorders Unit, Department of Neurology, Westmead Hospital, Sydney, NSW, Australia.

Handbook of Clinical Neurology

|November 29, 2018

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Tremor often involves hidden gait and balance issues, even if not clinically apparent. Research shows cerebellar networks are key to tremor, impacting posture and movement control.

Area of Science:

Neurology
Neuroscience
Movement Disorders

Background:

Tremor is a common symptom across diverse diseases with varying causes.
Patients with tremor may not report balance or gait problems, despite underlying deficits.
Quantitative and neurophysiologic studies reveal impaired gait and balance in tremor patients.

Purpose of the Study:

To investigate the link between tremor and impaired gait and balance.
To identify common pathophysiological mechanisms underlying tremor and postural instability.
To highlight the role of cerebellar networks in tremor and associated motor control deficits.

Main Methods:

Quantitative analysis of gait and posture.
Neurophysiologic techniques to assess neural function.

Keywords:

accidental falls cerebellum dystonia essential tremor gait orthostatic tremor postural balance tremor

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Epidemiologic studies to evaluate imbalance symptoms.

Neuroimaging studies to identify affected brain networks.

Main Results:

Laboratory studies demonstrate impaired gait and balance in various tremor types.
Epidemiologic data support the prevalence of imbalance symptoms in tremor patients.
Neuroimaging and neurophysiologic studies implicate cerebellar networks in tremor pathophysiology.
A common site of dysfunction in cerebellar networks explains the overlap in symptoms.

Conclusions:

Cerebellar networks are crucial mediators of tremor and are likely involved in impaired postural and gait control.
Understanding these cerebellar mechanisms is vital for developing novel treatments for tremor.
Further research into these networks could lead to new surgical or minimally invasive therapies for tremor disorders.