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Assessing Respiratory Immune Responses to Haemophilus Influenzae
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Assessing Respiratory Immune Responses to Haemophilus Influenzae

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Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed

Naoki Hara1, Takeaki Wajima2, Shoji Seyama2

  • 1Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|November 29, 2018
PubMed

Insights

Resistant Haemophilus influenzae strains are emerging in children with sinusitis. This strain acquired multiple antibiotic resistance genes, suggesting increased prevalence of such resistant bacteria.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Paediatrics

Background:

  • β-lactams and macrolides are common treatments for paediatric acute otitis media and sinusitis.
  • Streptococcus pneumoniae and Haemophilus influenzae are frequent causative agents.
  • Antimicrobial resistance in these pathogens is a growing concern.

Observation:

  • A Haemophilus influenzae strain was isolated from a paediatric patient with acute sinusitis.
  • This isolate was resistant to multiple antibiotics.
  • The resistance was attributed to specific genes: blaTEM-1, mef(A), and tet(M).

Findings:

  • The H. influenzae strain possessed exogenous resistance genes, blaTEM-1, mef(A), and tet(M).
  • DNA sequencing indicated potential transfer of mef(A) and tet(M) from Streptococcus species.
  • The patient had no history of excessive antibiotic exposure or underlying conditions.

Implications:

  • The presence of multiple exogenous resistance genes in H. influenzae suggests horizontal gene transfer.
  • This finding highlights the potential for increased prevalence of multi-drug resistant bacteria in outpatient settings.
  • Further surveillance is needed to monitor the spread of resistant H. influenzae strains in paediatric populations.
Keywords:
Exogenous genesHaemophilus influenzaemef(A)

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