Related Experiment Video

Updated: Feb 2, 2026

Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique
08:38

Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique

Published on: July 15, 2021

3.9K

Entrectinib Effective across NTRK Fusion-Positive Cancers

    Cancer Discovery
    |November 29, 2018
    PubMed

    Insights

    Entrectinib shows promise for solid tumors with NTRK gene fusions. Over half of patients responded, including those with brain metastases, indicating broad efficacy.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare but actionable drivers in various solid tumors.
    • Targeted therapies offer new treatment avenues for patients with specific genetic alterations.

    Discussion:

    • Entrectinib demonstrated significant clinical activity in a combined analysis of Phase I and II trials.
    • The drug's efficacy was observed across diverse tumor types harboring NTRK fusions.
    • Central nervous system (CNS) activity was notable, with a comparable response rate in patients with brain metastases.

    Key Insights:

    • Entrectinib is a potential therapeutic option for NTRK fusion-positive solid tumors.
    • Tumor-agnostic efficacy supports its use irrespective of primary tumor site.
    • Brain penetration and activity are crucial for patients with metastatic disease.

    Outlook:

    • Further investigation into long-term outcomes and resistance mechanisms is warranted.
    • Entrectinib may become a standard of care for NTRK fusion-positive cancers.
    • Exploration in combination therapies could enhance patient response and survival.

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