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Updated: Feb 2, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Synthesis and antimicrobial activity of 3,4-bis(arylthio)maleimides
Alexey A Panov1, Sergey N Lavrenov2, Alexander Y Simonov2
1Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, Russia, 119021. 7745243@mail.ru.
Abstract:
A series of 3,4-bis(arylthio)maleimides were synthesized and their antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria, including multidrug resistant (MDR) strains and some fungi. Most compounds turned out to be highly active, activity being dependent on substituents on phenyl rings.
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