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Termination of Translation

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...

Termination of Translation

Termination of Translation

Drag Force and Terminal Speed

Drag Force and Terminal Speed

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Riboswitches

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
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Related Experiment Video

Updated: Feb 2, 2026

Terminal H-reflex Measurements in Mice

Terminal H-reflex Measurements in Mice

Published on: June 16, 2022

Capecitabine-Associated Terminal Ileitis.

Irene E G van Hellemond¹, Annemarie M Thijs¹, Geert-Jan Creemers¹

¹Department of Internal Medicine, Catharina Hospital, Eindhoven, the Netherlands.

Case Reports in Oncology

|November 29, 2018

Summary

This summary is machine-generated.

Capecitabine, an oral chemotherapy for colorectal cancer, can cause severe diarrhea. This case highlights terminal ileitis as a rare, underreported side effect that clinicians should consider.

Keywords:

Adverse event Capecitabine Colorectal cancer Diarrhea Fluoropyrimidine Terminal Ileitis

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Area of Science:

Oncology
Gastroenterology
Pharmacology

Background:

Capecitabine is an oral fluoropyrimidine chemotherapy agent used for colorectal cancer.
Diarrhea is a common side effect associated with capecitabine and 5-fluorouracil treatments.
Understanding rare adverse events is crucial for patient management.

Observation:

A patient undergoing capecitabine treatment presented with severe and atypical diarrhea.
Diagnostic evaluation revealed terminal ileitis, inflammation of the terminal ileum.
This presentation was identified as a potential adverse event of capecitabine therapy.

Findings:

Terminal ileitis is a rare but significant adverse event associated with capecitabine treatment.
This condition may be underreported in clinical practice.
Capecitabine-induced terminal ileitis can manifest as severe, atypical diarrhea.

Implications:

Clinicians should consider capecitabine-induced terminal ileitis in patients experiencing severe diarrhea during treatment.
Increased awareness may improve diagnosis and management of this rare side effect.
Further investigation into the incidence and mechanisms of capecitabine-induced terminal ileitis is warranted.