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Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis

Jun-Li Chang1,2, Wen-Yi Wang1,2, Yi-Mian Li1,2

  • 1Orthopedic Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Chinese Journal of Integrative Medicine
|November 29, 2018
PubMed
Abstract

Insights

Chinese herbal medicine (CHM) shows significant potential in inhibiting osteosarcoma (OS) growth in mouse models. This meta-analysis supports CHM as a viable option for future preclinical and clinical trials in OS treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Osteosarcoma (OS) is a primary bone malignancy with limited effective treatments.
  • Chinese herbal medicine (CHM) has a long history of use in traditional medicine for various conditions.
  • Investigating the efficacy of CHM in preclinical models is crucial for potential therapeutic development.

Purpose of the Study:

  • To systematically review and critically evaluate the effects of CHM on tumor volume and weight in osteosarcoma mouse models.
  • To provide a quantitative summary of CHM's inhibitory impact on OS tumor growth.
  • To assess the potential of CHM as an adjuvant or alternative therapy for osteosarcoma.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, Embase, Web of Science, CNKI, Wanfang, VIP, CBM) up to March 2016.
  • Twenty-five randomized controlled studies involving CHM administration in vivo for osteosarcoma mouse models were included.
  • A pair-wise meta-analysis was performed to pool the data on tumor weight and volume.

Main Results:

  • CHM significantly inhibited osteosarcoma tumor weight (20 studies, n=443; pooled MD=-2.90, P<0.01) and tumor volume (16 studies, n=382; pooled MD=-2.57, P<0.01).
  • The tumor growth inhibition rate was also significantly affected by CHM treatment.
  • These findings indicate a consistent inhibitory effect of CHM on OS progression in mouse models.

Conclusions:

  • CHM demonstrates a significant inhibitory effect on osteosarcoma growth in mouse models.
  • The results suggest that CHM could be a supportive treatment strategy for osteosarcoma.
  • Further preclinical and clinical trials are warranted to explore the therapeutic potential of CHM for osteosarcoma.
Keywords:
Chinese herbal medicinemeta-analysismouseosteosarcomasystematic reviewxenograft model

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