Related Experiment Video
Updated: Feb 2, 2026

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
Published on: June 20, 2025
Typicality: Stable structures and flexible functions
Michael A Dieciuc1, Jonathan R Folstein2
1Department of Psychology, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA. dieciuc@psy.fsu.edu.
Abstract:
Some research suggests typicality is stable, other research suggests it is malleable, and some suggests it is unstable. The two ends of this continuum-stability and instability-make somewhat contradictory claims. Stability claims that typicality is determined by our experience of decontextualized feature correlations in the world and is therefore fairly consistent. Instability claims that typicality depends on context and is therefore extremely inconsistent. After reviewing evidence for these two claims, we argue that typicality's stability and instability are not contradictory but rather complementary when they are understood as operating on two different levels. Stability reflects how information gets encoded into semantic memory-what we call structural typicality. Instability reflects the task-dependent recruitment of semantic knowledge-what we call functional typicality. Finally, we speculate on potential factors that may mediate between the recruitment of structural or functional typicality.
Related Concept Videos
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Structural Protein Function
Fruit Development, Structure, and Function
Structure and Function of Erythrocytes
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Structure and Function of Leukocytes
White blood cells protect the body...

