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Structure and Function of the Cochaperone Prefoldin.

Rocío Arranz1, Jaime Martín-Benito1, José M Valpuesta2

  • 1Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

Advances in Experimental Medicine and Biology
|November 29, 2018
PubMed
Summary
This summary is machine-generated.

Prefoldin (PFD) is a cochaperone that assists molecular chaperones in protein folding. Recent studies reveal PFD has diverse roles beyond folding, including nuclear functions and interactions with other proteins.

Keywords:
CCTChaperoninCochaperoneElectron microscopyGroup II chaperoninMolecular chaperonePrefoldinProtein foldingTRiCThermosomeX-ray crystallography

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Molecular chaperones maintain proteostasis, essential for cellular protein balance.
  • Cochaperones, like prefoldin (PFD), modulate chaperone activity in protein synthesis, folding, and degradation.
  • PFD is a heterohexamer found in eukaryotes and archaea, primarily known for aiding Hsp60 chaperones in protein folding.

Purpose of the Study:

  • To review the structure and diverse functions of the prefoldin (PFD) macromolecular complex.
  • To explore PFD's roles beyond its canonical function in protein folding.
  • To highlight PFD's involvement in various cellular processes in both the cytosol and nucleus.

Main Methods:

  • Literature review of existing studies on prefoldin structure and function.
  • Analysis of research detailing PFD's interactions with other proteins and its oligomeric states.
  • Synthesis of findings on PFD's involvement in both cytosolic and nuclear processes.

Main Results:

  • Prefoldin (PFD) exhibits a complex role extending beyond its well-established function in protein folding.
  • PFD can form various oligomeric structures and complexes with other cellular proteins.
  • Emerging evidence indicates PFD participates in diverse cellular processes in both the cytosol and nucleus.

Conclusions:

  • Prefoldin (PFD) is a versatile cochaperone with multifaceted functions in cellular proteostasis.
  • Its ability to adopt different structures and interact with various partners underscores its broader cellular significance.
  • Further research into PFD's non-folding related activities is warranted to fully understand its biological impact.