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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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Basic Characteristics of Muse Cells.

Shohei Wakao1, Yoshihiro Kushida1, Mari Dezawa2

  • 1Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Advances in Experimental Medicine and Biology
|November 29, 2018
PubMed
Summary

Multilineage-differentiating stress-enduring (Muse) cells share key features with pluripotent stem cells, including self-renewal and differentiation. These unique cells possess distinct stress tolerance factors and environmental plasticity.

Keywords:
Bone marrowClusterConnective tissueDNA repairPeripheral bloodPrimed pluripotentSSEA-3Self-renewalSuspensionTrilineage differentiation

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Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Cellular plasticity

Background:

  • Multilineage-differentiating stress-enduring (Muse) cells are a type of adult stem cell with characteristics similar to pluripotent stem cells.
  • Pluripotent stem cells exist in two states: naive and primed, with distinct properties.
  • Understanding Muse cell characteristics is crucial for advancing stem cell therapies.

Purpose of the Study:

  • To provide a comprehensive overview of the fundamental properties of Muse cells.
  • To highlight the unique attributes of Muse cells compared to other pluripotent stem cells.
  • To position Muse cells within the broader context of stem cell classification.

Main Methods:

  • Review of existing literature on Muse cells and pluripotent stem cells.
  • Comparative analysis of Muse cell characteristics against embryonic stem cells.
  • Description of pluripotency regulation, cell division, and stress tolerance factors.

Main Results:

  • Muse cells express pluripotency markers and can differentiate into three lineages (trilineage differentiation) both in vitro and in vivo.
  • Muse cells exhibit self-renewability and unique properties like environmental control of pluripotency, distinct cell division patterns, and stress tolerance.
  • Muse cell properties align with primed pluripotent stem cells but possess unique features.

Conclusions:

  • Muse cells represent a distinct category of pluripotent stem cells with significant potential in regenerative medicine.
  • Their unique stress tolerance and plasticity offer advantages over traditional pluripotent stem cells.
  • Further research into Muse cells could unlock novel therapeutic applications.