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Liver Regeneration Supported by Muse Cells.

Satoshi S Nishizuka1, Yuji Suzuki2, Hirokatsu Katagiri3

  • 1Division of Biomedical Research and Development, Institute of Biomedical Sciences, Iwate Medical University, Morioka, Japan. snishizu@iwate-med.ac.jp.

Advances in Experimental Medicine and Biology
|November 29, 2018
PubMed
Summary

Multipotential progenitor cells, known as Muse cells, can regenerate liver tissue. These extrahepatic cells offer a promising new avenue for treating liver diseases, potentially improving patient outcomes.

Keywords:
ChimerismExtrahepatic cellsHepatectomyLiver regenerationLiving donor liver transplantMesenchymal stem cellsMultilineage-differentiating stress-enduring cellsPartial hepatectomyPhysical partial hepatectomySSEA-3

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Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Cell Biology

Background:

  • Liver disease treatment lacks significant advancements, with current modalities showing limited efficacy.
  • Cellular compensation from extrahepatic sources is a potential therapeutic strategy for liver diseases.
  • The exact mechanisms of liver regeneration and treatment effects at the cellular level remain unclear.

Purpose of the Study:

  • To review current liver disease therapeutics.
  • To discuss the potential of cell therapy using Multilineage-differentiating stress-enduring (Muse) cells for liver regeneration.
  • To present findings from Muse cell administration in a mouse model.

Main Methods:

  • Genotyping analysis of living donor liver transplantation grafts.
  • Review of current therapeutic strategies for liver diseases.
  • Administration of Muse cells in a mouse model of partial hepatectomy.

Main Results:

  • Genotyping confirmed differentiation of extrahepatic cells into liver components during regeneration.
  • Multilineage-differentiating stress-enduring (Muse) cells, identified by stage-specific embryonic antigen 3, show regenerative potential.
  • Muse cells possess advantages for clinical application due to their presence in various tissues and ethical considerations.

Conclusions:

  • Muse cells are a promising candidate for extrahepatic cellular compensation in liver regeneration.
  • Cell therapy using Muse cells represents a next-generation strategy for treating liver diseases.
  • Further studies on Muse cell administration support their potential therapeutic application.