Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacteria in ulcer pathogenesis.

N D Yeomans

    Bailliere'S Clinical Gastroenterology
    |July 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    The spiral bacteria, Campylobacter pylori, is strongly linked to causing chronic gastritis. While its role in gastric ulcers is uncertain, evidence suggests it may contribute to duodenal ulcers, though more research is needed.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Editorial: gastrointestinal safety of COX-2 selective and nonselective NSAIDs-the impact of the PRECISION trial. Authors' reply.

    Alimentary pharmacology & therapeutics·2018
    Same author

    Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial.

    Alimentary pharmacology & therapeutics·2018
    Same author

    Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors.

    Alimentary pharmacology & therapeutics·2016
    Same author

    Students coached for an admission test perform less well throughout a medical course.

    Internal medicine journal·2013
    Same author

    Predictors of gastroduodenal erosions in patients taking low-dose aspirin.

    Alimentary pharmacology & therapeutics·2009
    Same author

    Systematic review: ulcer definition in NSAID ulcer prevention trials.

    Alimentary pharmacology & therapeutics·2008
    Same journal

    Index.

    Bailliere's clinical gastroenterology·2020
    Same journal

    Home enteral and parenteral nutrition in children.

    Bailliere's clinical gastroenterology·1999
    Same journal

    Nutritional support in malnourished paediatric patients.

    Bailliere's clinical gastroenterology·1999
    Same journal

    Cholestasis and end-stage liver disease.

    Bailliere's clinical gastroenterology·1999
    Same journal

    Cystic fibrosis: nutritional consequences and management.

    Bailliere's clinical gastroenterology·1999
    Same journal

    Pancreatic diseases (excluding cystic fibrosis).

    Bailliere's clinical gastroenterology·1999
    See all related articles

    Area of Science:

    • Gastroenterology
    • Microbiology
    • Pathogenesis

    Background:

    • Recent research focuses on spiral bacteria, Campylobacter pylori, residing beneath the stomach's mucus layer.
    • This bacterium can also colonize metaplastic gastric cells in the duodenal bulb.
    • High prevalence of C. pylori is observed in patients with gastritis and duodenal ulcers.

    Purpose of the Study:

    • To investigate the etiological role of Campylobacter pylori in gastritis and peptic ulcers.
    • To evaluate the evidence linking C. pylori to active chronic gastritis.
    • To assess the potential causal relationship between C. pylori and gastric and duodenal ulcers.

    Main Methods:

    • Observational studies correlating C. pylori prevalence with specific gastrointestinal conditions.

    Related Experiment Videos

  • Experimental evidence from volunteer challenges and accidental infections.
  • Analysis of studies on gastritis fluctuations and C. pylori presence.
  • Review of antibiotic treatment outcomes and recurrence rates in ulcer patients.

    • Main Results:

    • Convincing evidence supports C. pylori as a cause of active chronic gastritis.
    • Gastritis development and symptoms observed in volunteers after C. pylori ingestion.
    • Fluctuations in gastritis severity correlate with C. pylori clearance and recrudescence.
    • C. pylori prevalence is high in duodenal ulcer patients, including children, suggesting a potential etiological role.

    Conclusions:

    • Campylobacter pylori is a confirmed cause of active chronic gastritis.
    • The bacterium's role in gastric ulcers remains uncertain.
    • Strong possibility exists for C. pylori's involvement in duodenal ulcers, supported by treatment and recurrence data.
    • Further definitive studies are required to confirm duodenal ulcers as an infectious disease.