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Updated: Feb 2, 2026
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
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[rTMS for treatment resistant depression - proposal for a treatment protocol].
Tijdschrift Voor Psychiatrie
|November 29, 2018
Summary
Repetitive transcranial magnetic stimulation (rtms) is a safe and effective treatment for treatment-resistant depression. This study proposes a clinical protocol for rtms in the Netherlands, recommending specific stimulation parameters for optimal outcomes.
Area of Science:
- Neurology
- Psychiatry
Background:
- Repetitive transcranial magnetic stimulation (rtms) is established for treatment-resistant depression.
- rtms will be reimbursed in the Netherlands when combined with cognitive behavior therapy.
Purpose of the Study:
- To propose a clinical treatment protocol for rtms in the Netherlands.
- To provide evidence-based guidelines for rtms application.
Main Methods:
- Literature review and critical appraisal of international rtms guidelines.
- Analysis of existing data on rtms efficacy and safety.
Main Results:
- rtms is safe for moderate to severe, treatment-resistant depression.
- Recommended protocol: left dorsolateral prefrontal cortex stimulation at 120% resting motor threshold, 10 Hz, 3000 pulses/session, 20-30 sessions.
- Duration of rtms effect remains unknown.
Conclusions:
- The proposed protocol is favored for acute symptom severity reduction in depression.
- Systematic data collection on rtms treatment is recommended for clinical practice improvement.
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