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Endocrine disruptors of the bisphenol and paraben families and bone metabolism

J Vitku1, L Kolatorova, L Franekova

  • 1Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic. jvitku@endo.cz.

Physiological Research
|November 29, 2018
PubMed

Insights

Postmenopausal osteoporosis may be linked to endocrine disruptors (EDs). Bisphenol A (BPA) showed a positive association with calcium levels, while methylparaben (MP) negatively correlated with bone resorption markers.

Area of Science:

  • Endocrinology
  • Environmental Health
  • Bone Metabolism

Background:

  • Decreased estrogen post-menopause allows endocrine disruptors (EDs) to affect bone remodeling and calcium-phosphate metabolism.
  • EDs are anthropogenic substances with estrogenic properties.
  • Bisphenol (BPA, BPS, BPF, BPAF) and paraben families are common EDs.

Purpose of the Study:

  • To measure specific EDs in postmenopausal women.
  • To assess the impact of EDs on calcium-phosphate metabolism and bone mineral density.
  • To investigate the relationship between EDs and osteoporosis in postmenopausal women.

Main Methods:

  • High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) measured unconjugated EDs in plasma.
  • Calcium-phosphate metabolism and bone mineral density were assessed.
  • Multiple linear regression analysis evaluated the impact of EDs on calcium-phosphate metabolism.

Main Results:

  • Bisphenol A (BPA) and methylparaben (MP) were detected in postmenopausal women with osteoporosis.
  • BPA showed a positive association with calcium (Ca) concentrations (beta=0.07, p<0.05).
  • MP demonstrated a negative association with C-terminal telopeptide (beta=-0.232, p<0.05).

Conclusions:

  • Preliminary findings suggest potential effects of BPA and MP on calcium-phosphate metabolism in postmenopausal women.
  • EDs like BPA and MP may play a role in bone health changes after menopause.
  • Further research is warranted to confirm these associations and elucidate mechanisms.

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